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Vacina contra a dengue é testada em voluntários de Porto Alegre

A vacina brasileira contra a dengue desenvolvida pelo Instituto Butantan será testada em voluntários da cidade de Porto Alegre (RS). Esta é a última etapa de testes antes de ser submetida à aprovação da Agência Nacional de Vigilância Sanitária (Anvisa) para ser produzida em larga escala e usada em campanhas de imunização.

Participam mil voluntários, com idade entre 18 a 59 anos. Uma equipe médica vai acompanhar os efeitos da vacina durante cinco anos. Os pesquisadores vão comparar a consistência da resposta imune entre os diferentes lotes da vacina.

Durante os testes, dois terços dos voluntários recebem a vacina e, no restante, é aplicado um placebo. A vacina foi produzida para proteger contra os quatro sorotipos da dengue com uma única dose.


Outros testes também estão em andamento em Manaus (AM), Fortaleza (CE), Boa Vista (RR), Porto Velho (RO), São José do Rio Preto (SP) e São Paulo (SP). No total, os testes envolverão 17 mil voluntários em 13 cidades brasileiras.

As vacinas foram desenvolvidas em parceria com os institutos nacionais de Saúde dos Estados Unidos. São produzidas com vírus vivos, mas geneticamente enfraquecidos, pois assim a resposta imunológica tende a ser mais forte. Os vírus presentes na vacina não têm potencial para provocar a dengue.

O Butantan já tem uma fábrica de pequena escala para produzir 500 mil doses da vacina por ano. Com algumas adaptações industriais, essa capacidade pode ser aumentada para até 12 milhões de doses ao ano. Existe um projeto de construção de uma planta de larga escala para produção de 60 milhões de doses ao ano.

Fonte: EBC

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